Green Tea with Rhubarb Root: Impact on Gut Microbiome and Lipids

Benefits of Green Tea and Herbal Ingredients on Health

Green tea, derived from the Camellia sinensis plant, is rich in polyphenols, particularly catechins, which have been shown to possess antioxidant, anti-inflammatory, and cholesterol-lowering properties (Lloyd et al., 2025). Various epidemiological and clinical studies have indicated that regular consumption of green tea is associated with reduced risks of cardiovascular diseases (CVD) through mechanisms that include improving lipid profiles and modulating gut microbiota (Yuan et al., 2018).

Rhubarb root, traditionally used in Chinese medicine, contains anthraquinones that contribute to its laxative effects and potential cholesterol-lowering properties (Zhu et al., 2024). The synergistic effects of combining green tea with rhubarb root may enhance the benefits of these ingredients, offering a multifunctional approach to health improvement.

A recent randomized controlled trial investigated the effects of green tea with rhubarb root on lipid profiles and gut microbiota in a healthy cohort. Participants who consumed the herbal infusion for 21 days experienced significant reductions in plasma total cholesterol, LDL cholesterol, and non-HDL cholesterol levels, while maintaining gut microbial stability (Lloyd et al., 2025).

Role of Gut Microbiota in Cardiovascular Health

The gut microbiota plays a critical role in metabolic and cardiovascular health. An imbalance in the gut microbiome, known as dysbiosis, has been linked to various conditions, including obesity, diabetes, and cardiovascular diseases (Tang et al., 2021). Specific microbial communities can influence host metabolism, inflammation, and overall health by modulating lipid metabolism and producing short-chain fatty acids (SCFAs) that contribute to gut health (Kobyliak et al., 2020).

Studies have shown that a diverse gut microbiota, characterized by a balanced ratio of Firmicutes and Bacteroidetes, can positively influence lipid profiles (Gumma et al., 2023). The consumption of green tea and herbal infusions has been associated with favorable changes in gut microbiota composition, leading to improved metabolic health and reduced risks of CVD (Lloyd et al., 2025).

Influence of Probiotics and Vitamins on Lipid Profiles

Probiotics and certain vitamins can also play significant roles in modulating gut microbiota and lipid metabolism. Probiotics, live microorganisms that confer health benefits to the host, can enhance the gut microbiome’s composition, promote SCFA production, and improve lipid profiles (Sivamaruthi et al., 2019). For instance, studies have shown that probiotic strains such as Bifidobacterium and Lactobacillus can reduce LDL cholesterol and triglyceride levels (Borgeraas et al., 2018).

Vitamin D, known for its role in bone health, has also been implicated in gut health and lipid metabolism. Research indicates that vitamin D deficiency is linked to dysbiosis and may exacerbate conditions such as ulcerative colitis (Zuo et al., 2023). The synergistic effects of probiotics and vitamins, alongside lifestyle modifications, create a multifaceted approach to managing obesity and related metabolic disorders.

Effects of Lifestyle Changes on Weight and Microbiome

Adopting a healthier lifestyle, which includes dietary modifications, physical activity, and stress management, can significantly impact gut microbiota composition and overall health. A study involving a community-engaged lifestyle intervention among factory workers demonstrated that such programs could lead to significant reductions in waist circumference, improved lipid profiles, and enhanced quality of life (Kobyliak et al., 2023). Participants who engaged in structured physical activities and received dietary guidance exhibited favorable changes in their gut microbiota, highlighting the importance of lifestyle factors in maintaining gut health.

Table 1: Impact of Lifestyle Changes on Clinical Parameters

Study Findings on Tea Consumption and Microbial Diversity

The exploration of herbal teas, particularly green tea with rhubarb root, has revealed promising results in enhancing gut microbial diversity while improving lipid profiles. The trial noted no significant changes in overall microbial composition, indicating that the gut microbiota remained stable despite the dietary intervention (Lloyd et al., 2025). However, specific genera such as Dorea spp. exhibited correlations with LDL cholesterol levels, suggesting a potential microbiota-mediated mechanism through which tea consumption may influence lipid metabolism.

Table 2: Changes in Gut Microbiota Composition

FAQ Section

What are the health benefits of green tea with rhubarb root?

Green tea with rhubarb root has demonstrated potential benefits in lowering total cholesterol, LDL cholesterol, and non-HDL cholesterol levels while maintaining gut microbial balance.

How does the gut microbiota influence cardiovascular health?

The gut microbiota can affect lipid metabolism, inflammation, and overall cardiovascular health. A balanced microbiota is associated with better metabolic outcomes and lower risks of cardiovascular diseases.

Can probiotics help in managing obesity?

Yes, probiotics can help improve gut microbiota composition, reduce inflammation, and support metabolic health, contributing to weight management.

What role do vitamins play in gut health?

Vitamins, particularly vitamin D and vitamin C, can influence gut microbiota composition and help maintain gut health, potentially impacting conditions like ulcerative colitis.

How can lifestyle changes enhance gut health?

Engaging in physical activity, adopting a healthy diet, and managing stress can promote a diverse and balanced gut microbiota, improving overall health and reducing the risk of chronic diseases.

References

1. Lloyd, A. J., Warren-Walker, A., Finch, J., Harper, J., Bennet, K., Watson, A., … & Beckmann, M. (2025). Green Tea with Rhubarb Root Reduces Plasma Lipids While Preserving Gut Microbial Stability in a Healthy Human Cohort. Metabolites, 15(1), 139. https://doi.org/10.3390/metabo15020139

2. Gumma, E. Z., Hayat, K., & Adak, A. (2023). The genus Cassia L.: Ethnopharmacological and phytochemical overview. Phytother. Res., 35(2), 336-382

3. Kobyliak, N., Conte, C., Cammarota, G., & Haley, A. P. (2023). Probiotics in prevention and treatment of obesity: A critical view. Nutrients, 15(12), 1236. https://doi.org/10.3390/nu15122763

4. Zuo, T., Zhang, F., Liu, Q., & Li, A. (2023). Impact of Vitamins, Antibiotics, Probiotics, and History of COVID-19 on the Gut Microbiome in Ulcerative Colitis Patients: A Cross-Sectional Study. Medicina, 61(2), 284. https://doi.org/10.3390/medicina61020284

5. Sivamaruthi, K. S., Kesika, P., & Chaiyasut, C. (2019). The role of probiotics in the management of obesity: A review. Nutrients, 11(2), 317. https://doi.org/10.3390/nu11020317

6. Borgeraas, H., Johnson, L. K., Skattebu, J., & Hjelmesaeth, J. (2018). Effects of probiotics on body weight, body mass index, fat mass, and fat percentage in subjects with overweight or obesity: A systematic review and meta-analysis of randomized controlled trials. Obes. Rev., 19(2), 219-232

7. Tang, W. H., Wang, Z., Levison, B. S., & Koeth, R. A. (2021). Gut microbiota and cardiovascular disease. Circulation Research, 127(5), 682-698

8. Kobyliak, N., Falalyeyeva, T., Boyko, N., & Tsyryuk, O. (2020). Probiotics and nutraceuticals as a new frontier in obesity prevention and management. Diabetes Res. Clin. Pract., 143, 101-128. https://doi.org/10.1016/j.diabres.2018.05.005