The article discusses the critical role of the endocannabinoid system (ECS) in eosinophilic esophagitis (EoE), a chronic inflammatory condition marked by eosinophil infiltration in the esophagus. The ECS, which comprises endocannabinoids, cannabinoid …
Nasal polyposis involves the formation of noncancerous growths in the nasal passages or sinuses, often linked to chronic inflammation. It affects 2% to 14% of the population, leading to symptoms such as nasal obstruction, loss of smell, and recurrent …
The article provides an overview of the current treatment strategies for eosinophilic esophagitis (EoE), emphasizing dietary interventions, pharmacological treatments, and endoscopic procedures. Dietary modifications, particularly elimination diets …
Eosinophilic gastrointestinal disorders (EGIDs) are linked to food allergies and abnormal immune responses, particularly involving type 2 helper T cells (Th2). Eosinophilic esophagitis (EoE) is localized to the esophagus, while eosinophilic …
Nasal polyposis (NP) is a chronic inflammatory condition characterized by nasal polyps that cause nasal obstruction and recurrent sinus infections. The condition is influenced by genetic, environmental, and immunological factors, with oxidative …
Usual Interstitial Pneumonia (UIP) is a progressive lung disease marked by dyspnea and cough, often associated with pulmonary fibrosis and respiratory failure. Patients with autoimmune conditions like rheumatoid arthritis and systemic sclerosis are …
Eosinophilic Granulomatosis with Polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a rare autoimmune disease causing systemic vasculitis mainly in individuals with asthma and elevated eosinophil levels. It presents with a variety of …
Eosinophilic gastroenteritis (EGE) is a rare gastrointestinal disorder marked by eosinophilic infiltration in the stomach and intestines, with an estimated prevalence of 8.4 per 100,000 individuals. Symptoms include abdominal pain, nausea, vomiting, …
The article discusses the shared genetic factors between asthma and chronic rhinosinusitis (CRS), highlighting their common type 2 inflammation characterized by elevated eosinophils and specific cytokines. Recent studies with over 1,200 CRS patients …
Epithelial barriers are crucial for protecting against environmental threats, but their dysfunction is linked to type 2 inflammatory diseases such as asthma, atopic dermatitis, and eosinophilic esophagitis. This dysfunction leads to an exaggerated …
Chronic rhinosinusitis (CRS) is a long-lasting inflammation of the nasal cavity and paranasal sinuses, affecting 5-12% of the population. It is categorized into two main phenotypes: CRS without nasal polyps (CRSsNP) and CRS with nasal polyps …
Hypereosinophilic Syndrome (HES) is characterized by a high eosinophil count in the blood, exceeding 1.5 × 10^9/L, and organ dysfunction due to eosinophilia. Clinical features include skin rashes, respiratory issues, cardiac problems, and …
Eosinophilic asthma is a subtype of asthma characterized by elevated eosinophils, leading to severe airway inflammation and resistance to standard treatments like inhaled corticosteroids. It is prevalent in about 50-60% of individuals with severe …
