The article discusses the role of Ubiquitin-specific peptidase 24 (USP24) in regulating lipogenesis, inflammation, and fibrosis in Metabolic Dysfunction-Associated Steatohepatitis (MASH), highlighting that USP24 inhibition can reduce body weight and …
The article discusses the clinical characteristics, laboratory indicators, treatment approaches, and outcomes for patients with sepsis and liver dysfunction, specifically Sepsis-Associated Liver Dysfunction (SALD). A study involving 95 patients …
Pediatric liver transplantation (LT) has progressed significantly over the last sixty years, beginning with the first successful procedure in 1963 on a 3-year-old boy. Japan has become a leader in living donor liver transplantation (LDLT), starting …
Nonalcoholic fatty liver disease (NAFLD) is a condition marked by excess fat accumulation in the liver, affecting over one-third of adults globally, often linked to obesity and Type 2 diabetes. NAFLD can progress to more severe forms like …
The article discusses the significant public health impact of Hepatitis B virus (HBV), a major cause of liver cancer. Chronic HBV infections can lead to severe complications such as liver cirrhosis and hepatocellular carcinoma (HCC) due to immune …
Liver health is crucial in managing hepatocellular carcinoma (HCC), a primary liver cancer often linked to chronic liver diseases like hepatitis B and C, alcoholic liver disease, and non-alcoholic fatty liver disease (NAFLD). Effective management of …
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD), involves fat accumulation in the liver unrelated to significant alcohol intake. This condition is increasingly prevalent …
Biliary atresia (BA) is a rare and serious liver condition in infants caused by the absence or obstruction of bile ducts, leading to liver damage and cholestasis. It is the primary reason for liver transplants in children, particularly prevalent in …
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a newly adopted term that encompasses various liver conditions linked to metabolic dysfunction, previously referred to as Non-Alcoholic Fatty Liver Disease (NAFLD). This shift aims …
The article discusses the significant immunometabolic challenges associated with liver xenotransplantation, primarily focusing on the immunogenic response from the recipient’s immune system, which often leads to acute rejection of xenografts. …
Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) is now the most common chronic liver disease worldwide, with approximately 1.27 billion cases reported in 2021. Its rise is linked to the global obesity epidemic, metabolic syndrome, and …
The article discusses Non-alcoholic fatty liver disease (NAFLD) and its connection to type 2 diabetes mellitus (T2DM), noting that over 50% of T2DM patients also have NAFLD. The bidirectional relationship between the two conditions complicates …
The article discusses the benefits of silymarin, a natural extract from milk thistle, in treating chronic liver disease (CLD). Key studies show silymarin’s effectiveness in improving liver function and lipid profiles, particularly in patients …
Spontaneous Bacterial Empyema (SBE) is a serious complication primarily affecting patients with liver cirrhosis, particularly those with hepatic hydrothorax, characterized by pus in the pleural cavity. This condition can lead to significant morbidity …
Hepatic hydrothorax is the accumulation of fluid in the pleural space due to liver disease, particularly cirrhosis. This condition arises when the liver’s impaired function leads to increased pressure in the portal vein, causing fluid to leak …
Zieve’s syndrome is a serious complication linked to chronic alcohol consumption, characterized by a triad of symptoms: jaundice, hemolytic anemia, and hyperlipidemia. First identified in the 1950s by Dr. Leslie Zieve, the syndrome often …
Understanding Acute Liver Failure: What You Need to Know Acute liver failure (ALF) is a sudden and severe liver dysfunction that can occur within days or weeks, often affecting individuals without prior liver disease history. Key causes include drug …
The article outlines the key differences between liver fibrosis and cirrhosis, both of which are stages of liver damage characterized by scar tissue accumulation. Liver fibrosis is an early stage where the liver attempts to repair itself after injury …
Cirrhosis is a progressive liver disease marked by the replacement of healthy liver tissue with scar tissue, leading to impaired liver function. It can result from chronic alcohol abuse, viral hepatitis, and metabolic disorders. Treatment focuses on …
Liver failure is a critical medical condition where the liver loses its ability to function properly, leading to severe health complications and potentially death. It can be classified into acute liver failure, which develops rapidly, and chronic …
Fatty liver disease is characterized by excess fat accumulation in liver cells, often linked to obesity, insulin resistance, type 2 diabetes, and metabolic syndrome. It can escalate to more severe conditions such as MASH, leading to liver …
Fatty liver disease, or steatosis, is the accumulation of excess fat in liver cells, affecting about one in ten people, particularly in Western countries. It can lead to serious complications such as steatohepatitis, cirrhosis, and liver failure. The …
The article provides an overview of liver cancer treatment, focusing on the complexities of managing this challenging disease, particularly Hepatocellular carcinoma (HCC). Treatment options vary based on cancer type, stage, and patient health, …
Chronic liver disease is a long-term condition characterized by liver damage and dysfunction, often progressing silently until significant harm occurs. Common causes include chronic viral infections (such as hepatitis B and C), excessive alcohol …
Cirrhosis is a progressive liver disease that leads to the replacement of healthy liver tissue with scar tissue, resulting in impaired liver function. It commonly arises from chronic liver damage caused by factors such as chronic viral hepatitis, …
Fatty liver disease, or hepatic steatosis, involves excess fat accumulation in liver cells and is primarily divided into alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD). NAFLD affects about 25% of the global …
The article discusses fatty liver disease, now known as metabolic dysfunction-associated steatotic liver disease (MASLD), which is characterized by fat accumulation in liver cells due to factors like obesity and insulin resistance. Often …
Cirrhosis, a progressive liver disease, can arise from various causes including chronic alcohol use, viral hepatitis (B and C), non-alcoholic fatty liver disease (NAFLD), genetic disorders, autoimmune diseases, and toxic exposure. Symptoms often …
Fatty liver disease, characterized by excess fat in liver cells, primarily includes alcoholic fatty liver disease (AFLD) and non-alcoholic fatty liver disease (NAFLD). NAFLD is closely associated with obesity, insulin resistance, and poor dietary …
Fatty liver disease, now known as metabolic dysfunction-associated steatotic liver disease (MASLD), involves excess fat accumulation in liver cells and is linked to metabolic dysfunction rather than alcohol use. It can progress through stages, …
Elevated liver enzymes indicate liver cell damage or inflammation and are commonly detected through routine blood tests. The primary enzymes measured include ALT, AST, ALP, and GGT. While elevated levels are often temporary and resolve without …
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease marked by fat accumulation, inflammation, and liver cell damage, potentially leading to serious conditions like cirrhosis and liver cancer. Its prevalence is increasing, particularly …
