The article discusses the significant role of histone H3K27 methylation (H3K27me3) in cancer biology, highlighting its involvement in gene expression regulation. Methylation at H3K27, primarily catalyzed by the enzyme EZH2, is associated with gene …
The article discusses the role of Thymus and activation-regulated chemokine (TARC), also known as CCL17, as a predictive biomarker for COVID-19 severity, particularly during the Omicron variant period. Research indicates that elevated TARC levels …
Chronic inflammation plays a significant role in various diseases, including cancer and autoimmune disorders. Recent research highlights CD109 as a key regulator in inflammatory responses, particularly through its interactions with TGF-β and NF-κB …
The article discusses the potential of ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8) as a novel therapeutic target in hepatocellular carcinoma (HCC), a significant global health issue with high incidence and mortality rates. ENTPD8, a …
The article emphasizes the significance of immune homeostasis in disease treatment, highlighting how the immune system balances activation and suppression to combat pathogens and prevent autoimmune diseases. Disruption of this balance can lead to …
Recent advances in biomedicine are reshaping multiple areas of patient care. In infant health, potent monoclonal antibodies against RSV have proven effective in reducing severe respiratory infections and hospitalizations by neutralizing diverse viral …
This article explores three cutting-edge areas in immunology and cancer research. The first section demonstrates that low-dose PMA effectively induces monocytes to differentiate into macrophages, marked by changes in cell morphology and an …
The article examines the mechanisms linking chronic stress to inflammation and cancer progression. Chronic stress activates the hypothalamic-pituitary-adrenal (HPA) axis, resulting in the release of stress hormones like cortisol, which modulate …
K-Ras mutations are significant oncogenic alterations found in various cancers, particularly pancreatic, colorectal, and lung cancers. The K-Ras protein acts as a molecular switch, and mutations, especially the aggressive G12D variant, lead to …
The article discusses the critical role of alternative splicing (AS) in T cell function and its implications for cancer immunotherapy. AS allows a single gene to produce multiple protein isoforms, enhancing T cell diversity and modulating immune …
The article discusses the significant role of circular RNA circPSD3 and microRNA miR-224-5p in papillary thyroid carcinoma (PTC). CircPSD3 is overexpressed in PTC tissues and correlates with tumor progression, suggesting its potential as a biomarker …
Traditional Chinese Medicine (TCM) is increasingly recognized for its significant role in cancer treatment, particularly in China, where it is valued for its efficacy, cost-effectiveness, and accessibility. TCM employs various modalities, including …
The article discusses the significance of TOM40, a key oncogene in Oral Squamous Cell Carcinoma (OSCC), which is a prevalent and aggressive form of head and neck cancer. TOM40 is crucial for mitochondrial function and is linked to increased tumor …
Immunotherapy is an innovative cancer treatment that utilizes the body’s immune system to identify and destroy cancer cells, contrasting traditional chemotherapy, which targets all rapidly dividing cells. Various immunotherapy types include …
